The scandal of the “biotechnology evangelist” erupted in Korea at the beginning of the new year: a commission from Seoul National University announced that it had proof that Dr Woo Suk Hwang, considered one of the world’s foremost experts on cloning by nucleus transfer, had manipulated the data concerning experiments in human cell cloning and the creation of eleven lines of stem cells from human embryos published in two different articles in the journal Science in 2004 and 2005.
This award is for a Science and Technology Center devoted to the emerging area of nanobiotechnology that involves a close synthesis of nano-microfabrication and biological systems. The Nanobiotechnology Center (NBTC) features a highly interdisciplinary, close collaboration between life scientists, physical scientists, and engineers from Cornell University, Princeton University, Oregon Health Sciences University, and Wadsworth Center of the New York State Health Department. The integrating vision of the NBTC is that nanobiotechnology will be the genesis of new insights into the function of biological systems, and lead to the design of new classes of nano- and microfabricated devices and systems. Biological systems present a particular challenge in that the diversity of materials and chemical systems for biological applications far exceeds those for silicon-based technology in the integrated-circuit industry. New fabrication processes appropriate for biological materials will require a substantial expansion in knowledge about the interface between organic and inorganic systems. The ability to structure materials and pattern surface chemistry at small dimensions ranging from the molecular to cellular scale are the fundamental technologies on which the research of the NBTC is based. Nanofabrication can also be used to form new analytical probes for interrogating biological systems with unprecedented spatial resolution and sensitivity. Three unifying technology platforms that foster advances in materials, processes, and tools underlie and support the research programs of the NBTC: Molecules of nanobiotechnology; Novel methods of patterning surfaces for attachment of molecules and cells to substrates; and Sensors and devices for nanobiotechnology. Newly developed fabrication capabilities will also be available through the extensive resources of the Cornell Nanofabrication Facility, a site of the NSF National Nanofabrication Users Network. The NBTC will be an integrated part of the educational missions of the participating institutions. NBTC faculty will develop a new cornerstone graduate course in nanobiotechnology featuring nanofabrication with an emphasis on biological applications. Graduate students who enter the NBTC from a background in engineering or biology will cross-train in the other field by engaging in a significant level of complementary course work. Participation in the NBTC will prepare them with the disciplinary depth and cross-disciplinary understanding to become next generation leaders in this emerging field. An undergraduate research experience program with a strong mentoring structure will be established, with emphasis on recruiting women and underrepresented minorities into the program. Educational outreach activities are planned to stimulate the interest of students of all ages. One such activity partnered with the Science center in Ithaca is a traveling exhibition for museum showings on the subject of nano scale size. National and federal laboratories and industrial and other partners will participate in various aspects of the NBTC such as by hosting interns, attendance at symposia and scientist exchanges. Partnering with the industrial affiliates will be emphasized to enhance knowledge transfer and student and postdoctoral training. This specific STC award is managed by the Directorate for Engineering in coordination with the Directorates for Biological Sciences, Mathematical and Physical Sciences, and Education and Human Resources.
This collaborative project aims to establish a national computational resource to move the research community much closer to the realization of the goal of the Tree of Life initiative, namely, to reconstruct the evolutionary history of all organisms. This goal is the computational Grand Challenge of evolutionary biology. Current methods are limited to problems several orders of magnitude smaller, and they fail to provide sufficient accuracy at the high end of their range. The planned resource will be designed as an incubator to promote the development of new ideas for this enormously challenging computational task; it will create a forum for experimentalists, computational biologists, and computer scientists to share data, compare methods, and analyze results, thereby speeding up tool development while also sustaining current biological research projects. The resource will be composed of a large computational platform, a collection of interoperable high-performance software for phylogenetic analysis, and a large database of datasets, both real and simulated, and their analyses; it will be accessible through any Web browser by developers, researchers, and educators. The software, freely available in source form, will be usable on scales varying from laptops to high-performance, Grid-enabled, compute engines such as this project's platform, and will be packaged to be compatible with current popular tools. In order to build this resource, this collaborative project will support research programs in phyloinformatics (databases to store multilevel data with detailed annotations and to support complex, tree-oriented queries), in optimization algorithms, Bayesian inference, and symbolic manipulation for phylogeny reconstruction, and in simulation of branching evolution at the genomic level, all within the context of a virtual collaborative center. Biology, and phylogeny in particular, have been almost completely redefined by modern information technology, both in terms of data acquisition and in terms of analysis. Phylogeneticists have formulated specific models and questions that can now be addressed using recent advances in database technology and optimization algorithms. The time is thus exactly right for a close collaboration of biologists and computer scientists to address the IT issues in phylogenetics, many of which call for novel approaches, due to a combination of combinatorial difficulty and overall scale. The project research team includes computer scientists working in databases, algorithm design, algorithm engineering, and high-performance computing, evolutionary biologists and systematists, bioinformaticians, and biostatisticians, with a history of successful collaboration and a record of fundamental contributions, to provide the required breadth and depth. This project will bring together researchers from many areas and foster new types of collaborations and new styles of research in computational biology; moreover, the interaction of algorithms, databases, modeling, and biology will give new impetus and new directions in each area. It will help create the computational infrastructure that the research community will use over the next decades, as more whole genomes are sequenced and enough data are collected to attempt the inference of the Tree of Life. The project will help evolutionary biologists understand the mechanisms of evolution, the relationships among evolution, structure, and function of biomolecules, and a host of other research problems in biology, eventually leading to major progress in ecology, pharmaceutics, forensics, and security. The project will publicize evolution, genomics, and bioinformatics through informal education programs at museum partners of the collaborating institutions. It also will motivate high-school students and college undergraduates to pursue careers in bioinformatics. The project provides an extraordinary opportunity to train students, both undergraduate and graduate, as well as postdoctoral researchers, in one of the most exciting interdisciplinary areas in science. The collaborating institutions serve a large number of underrepresented groups and are committed to increasing their participation in research.
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TEAM MEMBERS:
Tandy WarnowDavid HillisLauren MeyersDaniel MirankerWarren Hunt, Jr.
The "Salmon Research Team: A Native American Technology, Research and Science Career Exposure Program" is a three-year, youth-based ITEST project submitted by the Oregon Museum of Science and Industry. The project seeks to provide advanced information technology and natural science career exposure and training to 180 middle level and high school students. Mostly first-generation college-bound students, the target audience represents the Native American community and those with Native American affiliations in reservation, rural and urban areas. Students will investigate computer modeling of complex ecological, hydrological and geological problems associated with salmon recovery efforts. Field experiences will be provided in three states: Oregon, Washington and northern California. The participation of elders and tribal researchers will serve as a bridge between advanced scientific technology and traditional ecological knowledge to explore sustainable land management strategies. Students will work closely with Native American and other scientists and resource managers throughout the Northwest who use advanced technologies in salmon recovery efforts. Student participation in IT-dependent science enrichment and research activities involving natural science fields of investigation will occur year round. Middle school students are expected to receive at least 330 contact hours including a one-week summer research experience, a one-week spring break program, and seven weekends of residential programs during the school year. The high school component consists of 460 contact hours reflecting one additional week for the summer research experience. In addition to watershed and salmon recovery related research, students will be involved in other ancillary research projects. A vast array of partners are positioned to support the field research experience including, for example, the U.S. Department of the Interior, Redwood National State Park, College of Natural Resources and Sciences at Humboldt State University, Confederated Tribes of the Warm Springs, University of Oregon Institute of Marine Biology, University of Washington Columbia Basin Research project, the Northwest Center for Sustainable Resources at Chemeketa Community College and the Integrated Natural Resource Technology program at Mt. Hood Community College. The project is intended to serve as a model for IT-based youth science programs that address national and state education standards and are relevant to the cultural experience of Native American students. Two mentors will provide continued support to students: an academic mentor at the student's schools and a professional mentor from a local university or natural resource agency. Incentives will be provided for student participation including stipends and internships. Career exposure and work-related skills are integrated throughout the project activities and every program component. Creative strategies are used to encourage family involvement including, for example, salmon bakes and museum discounts.
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TEAM MEMBERS:
Travis Southworth-NeumeyerDaniel Calvert
The X-Tech program will bring together the Exploratorium and staff at five Beacon Centers to create an innovative technology program using STEM and IT activities previously tested at the Exploratorium. At each X-Tech Club, two Beacon Center staff and two Exploratorium Youth Facilitators will work with 20 middle school students each year for a total of 300 participants. Youth Facilitators are alumni of the Exploratorium's successful Explainer program and will receive 120 hours of training in preparation for peer mentoring. Each site will use the X-Tech hands-on curriculum that will focus on small technological devices to explore natural phenomenon, in addition to digital imaging, visual perception and the physiology of eyes. Parental involvement will be fostered through opportunities to participate in lectures, field trips and open houses, while staff at Beacon Centers will participate in 20 hours of professional development each year.
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TEAM MEMBERS:
Vivian AltmannDarlene LibreroVirginia WittMichael Funk
WNET is producing "The Human Spark," a multimedia project that includes a four-part television series (4 x 60 min) for national primetime broadcast on PBS, innovative outreach partnerships with museums, an extensive Web site and outreach activities, including a Spanish-language version and companion book. Hosted by Alan Alda, "The Human Spark" will explore the intriguing questions: What makes us human? Can the human spark be found in the differences between us and our closest genetic relative -- the great apes? Is there some place or process unique to the human brain where the human spark resides? And if we can identify it, could we transfer it to machines? The programs will explore these questions through presenting cutting-edge research in a number of scientific disciplines including evolution, genetics, cognitive neuroscience, behavioral science, anthropology, linguistics, AI, robotics and computing. The series will highlight opposing views within each field, and the interdisciplinary nature of science, including its intersection with the humanities. The series will develop a new innovative format, the "muse concept", which involves pairing the host with a different scientific expert throughout each program. The outreach plan is being developed with a consortium of four leading science museums, American Museum of Natural History in New York, Museum of Science in Boston, The Exploratorium in San Francisco, and the Fort Worth Museum of Science and History, paired with their respective local public television stations. An additional six museums and local broadcasters will be chosen through an RFP process to develop local initiatives around the series. Multimedia Research and Leflein Associates will conduct formative as well as summative evaluations of the series and web.
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TEAM MEMBERS:
William GrantJared LipworthGraham CheddBarbara Flagg
Understanding the Science Connected to Technology (USCT) targets information technology (IT) experiences in a comprehensive training program and professional support system for students and teachers in science, technology, engineering and mathematics (STEM). Participants have opportunities to assume leadership roles as citizen volunteers within the context of science and technology in an international watershed basin. Training includes collection, analysis, interpretation and dissemination of scientific data. BROADER IMPACTS: Building on a student volunteer monitoring program called River Watch, the USCT project enables student scientists to conduct surface water quality monitoring activities, analyze data and disseminate results to enhance local decision-making capacity. The project incorporates state and national education standards and has the potential to reach 173 school jurisdictions and 270,000 students. USCT will directly impact 81 teachers, 758 students and 18 citizen volunteers. The USCT project provides direct scientist mentor linkages for each participating school. This linkage provides a lasting process for life-long learning and an understanding of how IT and STEM subject matter is applied by resource professionals. Broader impacts include accredited coursework for teachers and students, specialized training congruent with the "No Child Left Behind Act of 2001," and building partnerships with Native American schools. INTELLECTUAL MERIT: The USCT project is designed to refocus thinking from static content inside a textbook to a process of learning that includes IT and STEM content. The USCT engages students (the next generation of decision makers) in discovery of science and technology and expands education beyond current paradigms and political jurisdictions.
The Ocean Institute (OI), in partnership with Scripps Institution of Oceanography (Scripps), Capistrano Valley Boys & Girls Clubs (BGC) and the Institute of Electrical and Electronics Engineers (IEEE), is developing "SeaTech," a multi-year, Youth-based ITEST program providing 120 female and minority middle and high school students from underserved populations with 391 contact hours of information technology (IT)-intensive oceanographic research experiences. SeaTech content focuses on understanding the acoustic behaviors of whales and dolphins, specifically, sound production, noise impacts and acoustic population census in California, the Bering Sea and the Southern Ocean. SeaTech offers a two-year core program for 13 & 14 year olds consisting of a "Breadth of Exposure" phase and a "Depth of Skills" phase totaling 299 hours. The core program has three distinct elements -- after-school clubs, field explorations and summer research institutes -- and is augmented with efforts before and after: an Early Pipeline Development phase (52 hours) for youth age 12, and Internships (40 hours) for youth age 15. The three-year ITEST grant will host three cohorts of 40 participants each. Each youth participant will receive 391 total contact hours. Through efforts directed at parents, SeaTech anticipates involving 60 parents in about 80 hours of activities each year. Coordinated through and with the expertise of Capistrano Valley BGC, recruitment will include orientation and information programs, a bilingual brochure and direct efforts by BGC staff. In addition, recruitment will happen from local schools. INTELLECTUAL MERIT: IT-based studies of marine mammal bio-acoustics will 'hook' student interest in after-school clubs, field explorations and summer research institutes. SeaTech advances understanding of the role of broader pipeline development in addressing chronic recruitment and retention problems in teen-targeted IT programs. BROADER IMPACTS: SeaTech programming has been meticulously and demonstrably integrated into the afterschool programming at the BGC. The SeaTech Club provides organizational structure to the teen activities at the BGC; however, the IT curriculum is also integrated into two nationally renowned extant structures called Career Launch and Club Tech. Findings from the project's examination of recruitment, retention and parental involvement will have broad implications to the field of informal science education.
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TEAM MEMBERS:
Harry HellingKelly ReynoldsJohn HildebrandCandice Dickens
KQED is requesting funds to produce weekly radio science news reports, a weekly television magazine program, a dynamic online website that supports and extends the broadcast material and to create and maintain an active consortium of 13 participating STEM organizations. The project's working title is "Quest: Exploring Our Natural World." Quest's goals are to raise the profile of STEM issues that affect or occur throughout the Northern California region and activate citizens to discuss and investigate STEM issues. STEM content will include research fields that include Physical Sciences, Life Sciences and Earth Sciences. Most of the stories will include content about the technology and engineering used to support scientific endeavors. The KQED Educational Network EdNet will administer the community and educational outreach initiatives, including creating viewer/listener guides, developing and delivering workshops, and providing information built around Quest media. The project design involves innovative use of multiple platforms and collaborative partnerships with local informal educational institutions. The project's collaborators include the Bay Institute, California Academy of Sciences, Chabot Space and Science Center, East Bay Regional Park District, Exploratorium, Girl Scouts, Lawrence Berkeley National Laboratory, Lawrence Hall of Science, Oakland Zoo and The Tech Museum of Innovation. Rockman Et Al will conduct the evaluation of the Quest initiative.
Over three years, Science Central is producing 624 television segments that will present current, ongoing research through local newscasts on ABC and NBC stations nationwide. In addition to the regular research segments, ScienCentral will produce six "sweeps" series per year focusing on important new fields of research including: nanotechnology, genetics/genomics, ocean science, global climate change and brain sciences. An advisory board of scientists, teachers, science journalists and public information officers help inform the producers about individual stories and evolving fields of research, and they provide access to scientists and field research. They also provide scientific input and check the stories for accuracy. To facilitate production and to assure that research is covered on an international basis, ScienCentral will establish a footage consortium to exchange science news video with major Canadian and European newscasters. They also will provide the news stories to science centers for use in their interactive exhibits and web sites.
A permanent exhibition entitled "Search for Extraterrestrial Life" will engage visitors at the New York Hall of Science in applying the fundamental biology of life on Earth to understanding the search for life elsewhere. The 4,000 sq. ft. exhibition and accompanying programs will engage visitors in learning more about the wide range of conditions that support life on Earth, and how these life requirements shape the search on Mars and other planetary objects for any existing life forms. In addition, the technologies and strategies that scientists are developing to detect any life elsewhere will be highlighted. It is expected that 500,000 visitors each year will participate with the exhibit and its associated programs. Another dissemination plan for the project will be posting fabrication drawings and scripts in readily accessible formats on the Internet. Copies of all computer interactives on electronic media will be available to science-technology centers, museums and other informal learning institutions.
The Ocean Institute will design, develop, evaluate and install "Sea Floor Science," a 5,200 sq. ft. site-wide exhibition designed in partnership with Scripps Institution of Oceanography, the Jet Propulsion Laboratory, and the Institute of Nautical Archaeology at Texas A&M University. "Sea Floor Science" will provide opportunities for families, students and the general public to use authentic oceanographic equipment, tools and technology to recreate a world of ocean research and discovery. Visitors will experience how oceanographers are exploring the largely unknown sea floor to permit better understanding of the origin of sediments and rocks, paleoclimate reconstruction as evidenced by marine microfossils, and the dynamics of oceanic lithospheres and margins. The project is a new approach to museum exhibits. It will test innovative convertibility solutions that enable public areas to serve as both teaching stations and effective exhibits. It will also implement cost-effective update strategies to keep visitors at the forefront of scientific research. "Sea Floor Science" will reach 4,000,000 people in 22 states including on-site and on-line visitors, multi-state teacher networks, videoconferencing participants, science professionals, and replication sites at science centers and aquaria nationally.