This collaborative project aims to establish a national computational resource to move the research community much closer to the realization of the goal of the Tree of Life initiative, namely, to reconstruct the evolutionary history of all organisms. This goal is the computational Grand Challenge of evolutionary biology. Current methods are limited to problems several orders of magnitude smaller, and they fail to provide sufficient accuracy at the high end of their range. The planned resource will be designed as an incubator to promote the development of new ideas for this enormously challenging computational task; it will create a forum for experimentalists, computational biologists, and computer scientists to share data, compare methods, and analyze results, thereby speeding up tool development while also sustaining current biological research projects. The resource will be composed of a large computational platform, a collection of interoperable high-performance software for phylogenetic analysis, and a large database of datasets, both real and simulated, and their analyses; it will be accessible through any Web browser by developers, researchers, and educators. The software, freely available in source form, will be usable on scales varying from laptops to high-performance, Grid-enabled, compute engines such as this project's platform, and will be packaged to be compatible with current popular tools. In order to build this resource, this collaborative project will support research programs in phyloinformatics (databases to store multilevel data with detailed annotations and to support complex, tree-oriented queries), in optimization algorithms, Bayesian inference, and symbolic manipulation for phylogeny reconstruction, and in simulation of branching evolution at the genomic level, all within the context of a virtual collaborative center. Biology, and phylogeny in particular, have been almost completely redefined by modern information technology, both in terms of data acquisition and in terms of analysis. Phylogeneticists have formulated specific models and questions that can now be addressed using recent advances in database technology and optimization algorithms. The time is thus exactly right for a close collaboration of biologists and computer scientists to address the IT issues in phylogenetics, many of which call for novel approaches, due to a combination of combinatorial difficulty and overall scale. The project research team includes computer scientists working in databases, algorithm design, algorithm engineering, and high-performance computing, evolutionary biologists and systematists, bioinformaticians, and biostatisticians, with a history of successful collaboration and a record of fundamental contributions, to provide the required breadth and depth. This project will bring together researchers from many areas and foster new types of collaborations and new styles of research in computational biology; moreover, the interaction of algorithms, databases, modeling, and biology will give new impetus and new directions in each area. It will help create the computational infrastructure that the research community will use over the next decades, as more whole genomes are sequenced and enough data are collected to attempt the inference of the Tree of Life. The project will help evolutionary biologists understand the mechanisms of evolution, the relationships among evolution, structure, and function of biomolecules, and a host of other research problems in biology, eventually leading to major progress in ecology, pharmaceutics, forensics, and security. The project will publicize evolution, genomics, and bioinformatics through informal education programs at museum partners of the collaborating institutions. It also will motivate high-school students and college undergraduates to pursue careers in bioinformatics. The project provides an extraordinary opportunity to train students, both undergraduate and graduate, as well as postdoctoral researchers, in one of the most exciting interdisciplinary areas in science. The collaborating institutions serve a large number of underrepresented groups and are committed to increasing their participation in research.
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TEAM MEMBERS:
Tandy WarnowDavid HillisLauren MeyersDaniel MirankerWarren Hunt, Jr.
SoundVision Productions is developing and distributing a series of ten, hour-long public radio documentaries that will explore the turbulent boundary between science and the humanities, capturing the present moment of tremendous scientific and scholarly ferment with the unique and intimate power of radio. By introducing the radio audience to the thoughts and voices of some of the world\'s most accomplished scientists, in conversations with the counterparts in the humanities, the series will look at recent developments in science including physics, molecular and cell biology, environmental science, cognitive psychology and neuroscience, and the multiple disciplines of the life sciences reflecting the increasingly subtle and widespread application of evolutionary theory. In each program, a careful account of new scientific ideas and discoveries will be placed within the context of historical and contemporary thought about the human and natural worlds. Barinetta Scott, the Executive Producer, has most recently been the Executive Producer for the highly regarded NSF funded NPR series, "The DNA Files." In developing this project, she will work closely with an advisory committee that includes: John Avise, Research Professor, Dept. of Genetics, University of Georgia Samuel Barondes, Professor and Director of the University of California San Francisco\'s Center for Neurobiology and Psychiatry Terrence Deacon, Associate Professor of Anthropology, Boston University Anne Foerst, Professor of Computer Science and Theology, St. Bonaventure University Ursula Goodenough, Dept. of Biology, Washington University, St. Louis William Irons, Professor of Anthropology, Northwestern University Gordon Kane, Professor of Physics, University of Michigan Jim Miller, Senior Program Associate for the AAAS Program of Dialogue Between Science and Religion W. Mark Richardson, Episcopal Priest, Associate Professor of Systematic Theology, General Theological Seminary Holmes Rolston, University Distinguished Professor in the Department of Philosophy, Colorado State University Michael Ruse, Professor of the Philosophy of Biology and Ethics, at Florida State University Mary Evelyn Tucker, Professor of Religion at Bucknell University Dorothy Wertz, Senior Scientist; Social Science, Ethics, and the Law; The Shriver Center.
Kikim Media requests $743,316 to produce four half-hour television documentaries and associated outreach programs based on Michael Pollan's best-selling book, The Botany of Desire. The project explores the reciprocal nature of people's relationship with plants. The programs focus on the connections between apples and the human desire for sweetness; tulips and the desire for beauty; marijuana and the desire for intoxication; and corn and our desire for control over nature. The project will increase public understanding of diverse subjects including genetics, evolution, cognition and biochemistry as well as biodiversity, genetic diversity and the consequences of their loss. The project will have a broad impact through a national primetime PBS broadcast, an outreach program targeting adult audiences, and an educational module delivering appropriate content (excluding intoxication) to middle and high school audiences. Knight-Williams Research Communications will conduct the evaluation for The Botany of Desire television broadcast and outreach efforts.
The James Agee Film Project is requesting funds to produce a four-part series of one-hour films on the environmental and social history of Appalachia. "APPALACHIA: A History of Mountains and People" will be the first series of films on the history of Appalachia and the first environmental history film ever made about a region in the United States. The project will demonstrate the dynamic interaction and inseparability of natural history and human history. By interweaving the discoveries and insights from scientific disciplines, including geology, ecology, biology and environmental science, with those of the humanities, the series will explore how the mountains have shaped human cultures and how people have shaped the mountains. "APPALACHIA: A History of Mountains and People" is made for national broadcast on PBS and is being co-sponsored by six Appalachian state PBS networks. The series is being produced in conjunction with the upcoming "Encyclopedia of Appalachia." Outreach programs include partnerships with many regional grassroots organizations, PBS stations and educational institutions to extend the film into a wide range of rural communities and schools. The Project Director/Writer of the series will be the Academy Award nominated filmmaker Ross Spears. Jamie Ross is co-producer/writer; Dr. George Constantz, the Science Writer/Content Director. Dr. Constantz is also currently the principal science and ecology editor of The Encyclopedia of Appalachia, which will be published in 2005. A distinguished group of scholars and scientists will contribute to the project. Dr. Gary Henry, Director of the Applied Research Center in Atlanta, will oversee the project evaluation.
Screenscope, Inc. is producing three annual "state of the environment" reports. The reports will consist of a yearly, ninety-minute, prime-time public television program and an extensive outreach initiative to engage families and the public in a variety of educational activities. The television programs will: Present an up-to-date "state of the environment" assessment of ecosystem performance and human health; Feature the year's most important environmental incidents; Highlight the year's most cutting-edge scientific breakthroughs and research dealing with environmental issues; Focus on community programs that have helped improve the quality of the environment over the past year. The outreach initiative will include: A Citizen Science Project with strong emphasis on family participation; Neighborhood workshops and coalitions organized by local PBS stations in association with the American Association for Advancement of Science and the World Resources Institute; An interactive web component including real-time environmental satellite data and visualizations; Local and national media events featuring the yearly release of a "State of the Environment" report; Partnerships will be developed with environmental organizations to help promote and implement the initiative's informal education activities. The project will be under the direction of Marilyn and Hal Weiner with the television programs being produced by their company, Screenscope. Anthony Janetos, Vice President and Chief of Programs at the World Resources Institute will have oversight responsibility for the science information presented in the Annual Report. Project advisors include: Bonnie Cohen, former Under Secretary of State for Management and Board member of CARE; Chet Cooper, former Deputy Director, Emerging Technologies, Battelle/Pacific Northwest National Laboratory; Robert Fri, Senior Fellow Emeritus at Resources for the Future and former Director of the National Museum of Natural History; Edward Frieman, Director Emeritus at of the Scripps Institution of Oceanography and Vice Chancellor of the University of California; Nay Htun, Dean of the University of Peace and former Assistant Secretary-General, United Nations Development Programme; Thomas Lovejoy, Science Advisor to the World Bank and the UN Foundation; Jessica Tuchman Mathews, President of the Carnegie Endowment for International Peace; Per Pinstrup-Andersen, Director-General, International Food Policy Research Institute; Maurice Strong, Chairman, Earth council and former Secretary-General of the United Nations Earth Summit in Rio de Janeiro. There also will be science advisors for each of the individual episodes.
The Maryland Science Center is producing a 40-minute large format film about the discovery and scientific interpretation of dinosaurs based on fossil finds from the Gobi Desert. The film will follow the summer 2004 expedition of the American Museum of Natural History (AMNH) and the Mongolian Academy of Science led by paleontologists Dr. Michael Novacek and Dr. Mark Norell. It will present the scientific evidence for how we know what we know about dinosaurs and will examine such questions as what types of dinosaurs roamed the Gobi, what their environment was like, and what they tell us about the evolution of life on Earth. Greg Andorfer will be Executive Producer. The film will be produced by David Clark and co-directed by Clark and Bayley Silleck.
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TEAM MEMBERS:
Gregory AndorferDavid ClarkJames O'LearyBayley SilleckMichael Novacek
Sesame Workshop created a new planetarium show and outreach activities for children ages 5 and 6 and their families, teachers and other caregivers. The Adler Planetarium & Astronomy Museum, the Beijing Planetarium and the Liberty Science Center also collaborated on the "sharing the sky" themed show to help Chinese and American children identify differences and similarities in their respective associations to astronomy.