The scientific institution in Brazil is marching to a good rhythm. Despite problems in funding (and in the very irregular distribution of such funds), universities and private research centers changed and grew over the last few years. In 1999, Brazil (whose external debt is over 50% of GDP), invested 0.87% of GDP in Research & Development: a percentage comparable to that of several Mediterranean countries.
Free information works. In the sense that Open Access Journals, scientific journals which can be accessed at no cost, thereby guaranteeing free access to everyone, are at the same time able to guarantee the same quality as or even better than- that of traditional journals, which can only be read by those willing to pay a price, be it the cover price or a subscription.
This collaborative project aims to establish a national computational resource to move the research community much closer to the realization of the goal of the Tree of Life initiative, namely, to reconstruct the evolutionary history of all organisms. This goal is the computational Grand Challenge of evolutionary biology. Current methods are limited to problems several orders of magnitude smaller, and they fail to provide sufficient accuracy at the high end of their range. The planned resource will be designed as an incubator to promote the development of new ideas for this enormously challenging computational task; it will create a forum for experimentalists, computational biologists, and computer scientists to share data, compare methods, and analyze results, thereby speeding up tool development while also sustaining current biological research projects. The resource will be composed of a large computational platform, a collection of interoperable high-performance software for phylogenetic analysis, and a large database of datasets, both real and simulated, and their analyses; it will be accessible through any Web browser by developers, researchers, and educators. The software, freely available in source form, will be usable on scales varying from laptops to high-performance, Grid-enabled, compute engines such as this project's platform, and will be packaged to be compatible with current popular tools. In order to build this resource, this collaborative project will support research programs in phyloinformatics (databases to store multilevel data with detailed annotations and to support complex, tree-oriented queries), in optimization algorithms, Bayesian inference, and symbolic manipulation for phylogeny reconstruction, and in simulation of branching evolution at the genomic level, all within the context of a virtual collaborative center. Biology, and phylogeny in particular, have been almost completely redefined by modern information technology, both in terms of data acquisition and in terms of analysis. Phylogeneticists have formulated specific models and questions that can now be addressed using recent advances in database technology and optimization algorithms. The time is thus exactly right for a close collaboration of biologists and computer scientists to address the IT issues in phylogenetics, many of which call for novel approaches, due to a combination of combinatorial difficulty and overall scale. The project research team includes computer scientists working in databases, algorithm design, algorithm engineering, and high-performance computing, evolutionary biologists and systematists, bioinformaticians, and biostatisticians, with a history of successful collaboration and a record of fundamental contributions, to provide the required breadth and depth. This project will bring together researchers from many areas and foster new types of collaborations and new styles of research in computational biology; moreover, the interaction of algorithms, databases, modeling, and biology will give new impetus and new directions in each area. It will help create the computational infrastructure that the research community will use over the next decades, as more whole genomes are sequenced and enough data are collected to attempt the inference of the Tree of Life. The project will help evolutionary biologists understand the mechanisms of evolution, the relationships among evolution, structure, and function of biomolecules, and a host of other research problems in biology, eventually leading to major progress in ecology, pharmaceutics, forensics, and security. The project will publicize evolution, genomics, and bioinformatics through informal education programs at museum partners of the collaborating institutions. It also will motivate high-school students and college undergraduates to pursue careers in bioinformatics. The project provides an extraordinary opportunity to train students, both undergraduate and graduate, as well as postdoctoral researchers, in one of the most exciting interdisciplinary areas in science. The collaborating institutions serve a large number of underrepresented groups and are committed to increasing their participation in research.
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TEAM MEMBERS:
Tandy WarnowDavid HillisLauren MeyersDaniel MirankerWarren Hunt, Jr.
The Self-Reliance Foundation (SRF) Conociendo Tu Cuerpo (Know Your Body) Hispanic Community Health Sciences Education project is an initiative designed to introduce Hispanic students and families to biomedical science and health education resources, and increase their participation levels in these fields. The educational goals of the project are to: (1) Encourage Hispanic undergraduate students to pursue careers in biomedicine and science through a mentoring program at the university level; (2) Inspire an interest in biomedical science among Hispanic elementary-age students and parents through community outreach activities; (3) Inform Hispanic parents about biomedical science education standards and academic requirements for pursuing biomedical and science related careers; and (4) Inform and inspire Hispanic students and their families about the biomedical sciences and related careers through a series of daily nationally broadcast Spanish-language radio capsules, and a nationally syndicated Spanish newspaper column. Conociendo Tu Cuerpo (Know Your Body) includes several key components: A model, Washington, D.C., area coalition of informal science, health, community, education, and media organizations that will publicize and provide hands-on health science activities at community festivals and other community settings; Hispanic undergraduate student health-science fellows to be trained and provided experience in facilitating health science activities; and nationally broadcast Spanish-language radio capsules that will cover topics in areas of biomedicine, research, education, and health-science careers. Parents and students will be able to access additional information about biomedical science opportunities and Hispanic role models in the biomedical sciences through the project's Conociendo Tu Cuerpo website and the bilingual 800 telephone help line promoted by 147 participating radio stations and 102 newspapers nationwide. The project will be supported at the national level through collaboration with the Hispanic Radio Network and the Pacific Science Center. The Washington, D.C., collaborative will include the Capital Children's Museum, local Spanish language radio stations, area universities, and health and community organizations. Development Associates, the largest American education and evaluation consulting corporation, will evaluate the project.
The Miami Museum of Science, in collaboration with University of Miami's (UM) School of Medicine, is requesting a Phase II grant to support national replication of the Biomedical Training, Research and College Prep (BioTrac) Project. The goal of Phase I, now in its final year of funding, was to develop a replicable model aimed at increasing the numbers of underserved students entering the biomedical research pipeline. Phase I focused on priority areas under Healthy People 2000 reflecting health issues of interest to the community as well as resources available through UM's Jackson Memorial Medical Center. Comprising hands-on project-based programming, career awareness activities, college prep, research internships and college residential experiences, the project has served 98 students to date, of whom 88% are low-income and 96% reside in homes where English is the second language. Of the 43 seniors who have graduated to date, 42 are enrolled in post-secondary studies. Of these, 52% have chosen a science-related major, and of these, 73% have chosen a biomedical course of study. Under the proposed Phase II project, the useum will establish BioTrac as a national demonstration site, extending BioTrac strategies and materials to formal and informal science institutions (ISis) through site-based institutes, distance-learning opportunities and professional conferences and publications. Continued delivery of BioTrac programming at the demonstration site will also further increase the number of underrepresented students entering the biomedical research pipeline, and allow for further programming aimed at increasing public understanding of Healthy People 2010 priorities and biomedical research. The museum will target ISis with youth programs to attend a three-day replication institute, reaching a minimum of 30 ISis during the grant. Through participation in national conferences and professional development sponsored by the Association of Science-Technology Centers, representng 340 ISis, the model has the capacity to impact small, medium, and large science centers nationwide. The model will also be adaptable for use by the other 123 Upward Bound Math & Science Centers engaged in science enrichment programming for underserved youth. Finally, elements of the model will be suitable for extracurricular school-based science clubs and high school magnet programs focused on biomedicine, further extending the potential impact of the model to school districts nationwide.
BioTrac will expand opportunities in biomedicine for low-income, first-generation college-bound high school students, increasing the number interested in, and prepared to enter, the biomedical research pipeline. Specific objectives are to: (1) Raise awareness of careers in biomedicine and provide students with real-world biomedical research experiences; (2) Increase awareness of requirements and opportunities for related post-secondary study; (3) Increase public understanding of the importance and diversity of biomedical research; and (4) Disseminate project outcomes. In collaboration with the University of Miami (UM) and Miami-Dade County Public Schools (M-DCPS), the Museum will design and implement a replicable model program exposing students to research on selected priority areas outlined in the Public Health Service's Healthy People 2000 agenda. The program will focus on areas with significant local research capacity, ties to local growth industries, and relevance to Miami-Dade's diverse communities. Students will investigate each area through hands-on lab activities, on-line research, site visits to research facilities, and through interactions with research scientists at UM's nationally renowned Jackson Memorial Medical Complex. Students will work in teams to conduct community-focused research on aspects of each priority area, using technology skills acquired as part of the program to document their research through digital video, PowerPoint presentations, and development of a BioTrac website. Students will present their research at annual symposia held at the Museum. They will also serve as science explainers in the Museum's galleries, interpreting biomedical-related exhibits to the general public. During the summer before 12th grade, students will attend residential programs at University of Florida and Florida A&M University, gaining exposure to post-secondary programs leading to careers in biomedical research. Students in 11th and 12th grade will also be encouraged to participate in M-DCPS's Advanced Academic Internship Program, gaining up to three honors credits for work in institutions engaged in biomedical research. Following 12th grade, prior to beginning college, students will be placed in an eight-week summer internships at UM labs engaged in a broad spectrum of biomedical research. The Museum will disseminate students' research experiences and project findings through an BioTrac web page, ASTC and Upward Bound conferences and networks, and Museum and UM publications.